It is said that the village owes its name to a certain “asklipieio” (sanctuary of Asclepius) that existed in antiquity, but no such trace has been found. A hallmark of Asklipio village is the small castle of the Knights of Saint John, located at hilltop. It was built by the Byzantines and restored by the Master Pierre d’ Aubusson in 1474-79. In the centre of Asklipio stands perhaps the oldest Byzantine church of the island, Kimisi tis Theotokou (the Assumption of the Virgin Mary).